Effects of the sigma‑1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy

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T. Reyes et al.2021.Effects of the sigma‑1 receptor agonist blarcamesine in a murine model of fragile X syndrome. neurobehavioral phenotypes and receptor occupancy.pdf (1.45 MB)

Date

2021-08-25

Document type

Artículo

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Investigación
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Authors

Reyes, Samantha T., Deacon, Robert M. J., Guo, Scarlett G., Altimiras Gonzalez, Francisco Javier., Castillo, Jessa B., Van Der Wildt, Berend., Morales, Aimara P., Hyung Park, Jun., Klamer, Daniel, Rosenberg, Jarrett, Oberman, Lindsay M., Rebowe, Nell, Sprouse, Jeffrey, Missling, Christopher U., McCurdy, Christopher R., Cogram, Patricia, Kaufmann, Walter E., Chin, Frederick T.

Faculty

Facultad de Ingeniería y Negocios

Publisher

Nature Portfolio

URI

http://repositorio.udla.cl/xmlui/handle/udla/1051, https://www.nature.com/srep/

DOI

https://doi.org/10.1038/s41598-021-94079-7

Keywords

FMR1 knockout mice, Mouse model, ANAVEX2-73

Citation

Scientific Reports, 11(1), 14 p.

Extent

14 páginas
1.447Mb

Abstract

Fragile X syndrome (FXS), a disorder of synaptic development and function, is the most prevalent genetic form of intellectual disability and autism spectrum disorder. FXS mouse models display clinical...

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