Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy

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T. Reyes et al.2021.Effects of the sigma‑1 receptor agonist blarcamesine in a murine model of fragile X syndrome. neurobehavioral phenotypes and receptor occupancy.pdf (1.45 MB)

Date

2021-08-25

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journal article

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Investigación
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Authors

Reyes, Samantha T., J. Deacon, Robert M., Guo, Scarlett G., Altimiras, Francisco J., Castillo, Jessa B., der Wildt, Berend van, Morales, Aimara P., Park, Jun Hyung, Klamer, Daniel, Rosenberg, Jarrett, Oberman, Lindsay M., Rebowe, Nell, Sprouse, Jeffrey, Missling, Christopher U., McCurdy, Christopher R., Cogram, Patricia, Kaufmann, Walter E., Chin, Frederick T.

Publisher

Springer Science and Business Media LLC

URI

https://repositorio.udla.cl/handle/udla/1051

DOI

https://doi.org/10.1038/s41598-021-94079-7

Keywords

FMR1 KNOCKOUT MICE, MOUSE MODEL, AUTISM, BDNF, RADIOLIGAND, GENERATION, ANAVEX2-73

Citation

Scientific Reports, 11(1), 17150. https://doi.org/10.1038/s41598-021-94079-7

Abstract

Abstract Fragile X syndrome (FXS), a disorder of synaptic development and function, is the most prevalent genetic form of intellectual disability and autism spectrum disorder. FXS mouse models display...

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Creative Commons Attribution 4.0 International
Except where otherwised noted, this item's license is described as Creative Commons Attribution 4.0 International
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