Chronic bryostatin-1 rescues autistic and cognitive phenotypes in the fragile X mice

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Date

2020-10-22

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journal article

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Authors

Cogram, Patricia, Alkon, Daniel L., Crockford, David, J. Deacon, Robert M., Hurley, Michael J., Altimiras, Francisco, Sun, Miao-Kun, Tranfaglia, Michael

Publisher

Springer Science and Business Media LLC

URI

https://repositorio.udla.cl/handle/udla/852

DOI

https://doi.org/10.1038/s41598-020-74848-6

Keywords

Animals, Autism Spectrum Disorder, Behavior, Animal, Bryostatins, Cognition Disorders, Fragile X Syndrome, Learning, Mice, Inbred C57BL, Mice, Knockout, Phenotype, Protein Kinase C, Spatial Memory, bryostatin, bryostatin 1, protein kinase C, animal, animal behavior, autism, C57BL mouse, cognitive defect, fragile X syndrome, genetics, knockout mouse, learning, metabolism, phenotype, physiology, spatial memory

Citation

Scientific Reports, 10(1), 18058. https://doi.org/10.1038/s41598-020-74848-6

Abstract

Abstract Fragile X syndrome (FXS), an X-chromosome linked intellectual disability, is the leading monogenetic cause of autism spectrum disorder (ASD), a neurodevelopmental condition that currently has...

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Creative Commons Attribution 4.0 International
Except where otherwised noted, this item's license is described as Creative Commons Attribution 4.0 International
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