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Gestational hypothyroxinemia causes an inflammatory environment at maternal-fetal tissues and fetal brain with impaired hippocampal dendritic spine maturation in the offspring

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Date

2025-12

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journal article

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Authors

González-Madrid, Enrique, Rangel-Ramírez, Ma. Andreina, Opazo, María C., Espinoza, Sebastián A., Elgueta, Daniela, Cancino, Gonzalo I., Mery, Elena, Ardiles, Álvaro O., Duarte, Luisa F., Soto, Jorge A., Carreño, Leandro J., Simon, Felipe, Bueno, Susan M., González, Pablo A., Kalergis, Alexis M., Riedel, Claudia A.

Publisher

Nature Research

URI

https://repositorio.udla.cl/handle/udla/2180

DOI

https://doi.org/10.1038/s41598-025-26206-7

Keywords

Gestational hypothyroxinemia, Prenatal inflammation, Cytokines, Maternal-fetal interface, Embryonic neurodevelopment, Microglia, Hippocampal dendritic spines 1Millennium Institute on Immunology and Immunotherapy, Santiago

Citation

González-Madrid, Enrique; Rangel-Ramírez, Ma. Andreina; Opazo, María C.; Espinoza, Sebastián A.; Elgueta, Daniela; Cancino, Gonzalo I.; Mery, Elena; Ardiles, Álvaro O.; Duarte, Luisa F.; Soto, Jorge A.; Carreño, Leandro J.; Simon, Felipe; Bueno, Susan M.; González, Pablo A.; Kalergis, Alexis M.; Riedel, Claudia A. (2025). Gestational hypothyroxinemia causes an inflammatory environment at maternal-fetal tissues and fetal brain with impaired hippocampal dendritic spine maturation in the offspring. Scientific Reports, 15(1), 42160. https://doi.org/10.1038/s41598-025-26206-7

Abstract

Gestational hypothyroxinemia (HTX) is associated with cognitive impairments and autism traits in offspring. However, the underlying mechanisms remain unclear. Prenatal inflammation impairs cortical de...

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