Transfer of T6SSSPI-19from Salmonella Gallinarum to Salmonella Typhimurium Lacking T6SSSPI-6Complements its Colonization Defect in Mice

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dc.contributor.affiliationUniversidad de Las Americas - Chile
dc.contributor.affiliationUniversidad Bernardo O'Higgins
dc.contributor.affiliationUniversidad Andres Bello
dc.contributor.affiliationUniversidad de Chile
dc.contributor.authorPezoa, David
dc.contributor.authorBlondel, Carlos J.
dc.contributor.authorAmaya, Fernando A.
dc.contributor.authorSantiviago, Carlos A.
dc.date.accessioned2024-09-03T19:19:01Z
dc.date.available2024-09-03T19:19:01Z
dc.date.issued2023-06-01
dc.description.abstractAbstract Salmonella genus harbors five Type VI Secretion System (T6SS) gene clusters. The T6SS encoded in SPI-6 (T6SS SPI-6 ) contributes to Salmonella Typhimurium colonization of chickens and mice, while the T6SS encoded in SPI-19 (T6SS SPI-19 ) of Salmonella Gallinarum contributes to chicken colonization. Interestingly, the T6SS SPI-19 of Salmonella Gallinarum complemented the defect in chicken colonization of a Salmonella Typhimurium strain that lacks the T6SS SPI-6 , suggesting that both T6SSs are interchangeable. Here we show that the transfer of Salmonella Gallinarum T6SS SPI-19 complemented the defect in mice colonization of a Salmonella Typhimurium ΔT6SS SPI-6 strain, indicating that both T6SSs are functionally redundant during host colonization.
dc.description.sponsorshipFondo Concursable Proyectos de Investigacion Regulares UDLA [55008749]; FONDECYT [21191925]; CONICYT/ANID fellowship [ECOS200037]; ECOS-ANID; HHMI-Gulbenkian International Research Scholar Grant; DP was supported by Fondo Concursable Proyectos de Investigacion Regulares UDLA 2023 DI-13/23. CAS was supported by FONDECYT grant 1212075. CJB was supported by FONDECYT grant 1201805, ECOS-ANID ECOS200037 and HHMI-Gulbenkian International Research Scholar Grant #55008749. FA was supported by CONICYT/ANID fellowship 21191925.
dc.format.mimetypeapplication/pdf
dc.identifier.citationPolish Journal of Microbiology, 72(2), 215-219. https://doi.org/10.33073/pjm-2023-017
dc.identifier.doihttps://doi.org/10.33073/pjm-2023-017
dc.identifier.folio21191925
dc.identifier.folio1201805
dc.identifier.folio1212075
dc.identifier.folioECOS200037
dc.identifier.folio55008749
dc.identifier.issn2544-4646
dc.identifier.orcidhttps://orcid.org/0009-0005-7872-2374
dc.identifier.orcidhttps://orcid.org/0000-0002-7043-7908
dc.identifier.orcidhttps://orcid.org/0000-0002-7099-6347
dc.identifier.pmid37314360
dc.identifier.researcheridITU-2404-2023
dc.identifier.researcheridN-9991-2018
dc.identifier.researcheridPJC-2338-2026
dc.identifier.rorhttps://ror.org/00x0xhn70
dc.identifier.rorhttps://ror.org/0166e9x11
dc.identifier.rorhttps://ror.org/01qq57711
dc.identifier.rorhttps://ror.org/047gc3g35
dc.identifier.scopusauthorid55633809600
dc.identifier.scopusauthorid22936642500
dc.identifier.scopusauthorid57193734756
dc.identifier.scopusauthorid6507214143
dc.identifier.urihttps://repositorio.udla.cl/handle/udla/1393
dc.language.isoeng
dc.publisherPolish Society of Microbiologists
dc.relation.fundingHHMI-Gulbenkian, (55008749)
dc.relation.fundingComisión Nacional de Investigación Científica y Tecnológica, CONICYT, (21191925)
dc.relation.fundingComisión Nacional de Investigación Científica y Tecnológica, CONICYT
dc.relation.fundingFondo Nacional de Desarrollo Científico y Tecnológico, FONDECYT, (1201805, 1212075, ECOS-ANID ECOS200037)
dc.relation.fundingFondo Nacional de Desarrollo Científico y Tecnológico, FONDECYT
dc.relation.fundingFondo Concursable Proyectos de Investigacion Regulares UDLA [55008749]
dc.relation.fundingFONDECYT [21191925]
dc.relation.fundingCONICYT/ANID fellowship [ECOS200037]
dc.relation.fundingECOS-ANID
dc.relation.fundingHHMI-Gulbenkian International Research Scholar Grant
dc.relation.isindexedbyWeb of Science
dc.relation.issn2544-4646
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourcePOLISH JOURNAL OF MICROBIOLOGY
dc.source.urihttps://doi.org/10.33073/pjm-2023-017
dc.subjectSalmonella Typhimurium
dc.subjectT6SS
dc.subjectSPI-19
dc.subjectmice
dc.subjectcolonization
dc.subject.lcshColonización
dc.subject.lcshRatones
dc.subject.lcshSalmonella typhimurium
dc.subject.oecd11 Ciencias Naturales
dc.subject.oecd21.6 Ciencias Biológicas
dc.subject.oecd31.6.2 Microbiología
dc.titleTransfer of T6SSSPI-19from Salmonella Gallinarum to Salmonella Typhimurium Lacking T6SSSPI-6Complements its Colonization Defect in Mice
dc.title.alternativeTransfer of T6SS SPI-19 from Salmonella Gallinarum to Salmonella Typhimurium Lacking T6SS SPI-6 Complements its Colonization Defect in Mice
dc.title.alternativeTransfer of T6SSSPI-19 from Salmonella Gallinarum to Salmonella Typhimurium Lacking T6SSSPI-6 Complements its Colonization Defect in Mice
dc.title.alternativeTransfer of T6SSSPI-19 from Salmonella Gallinarum to Salmonella Typhimurium Lacking T6SSSPI-6 Complements its Colonization Defect in Mice.
dc.typejournal article
dc.type.coarhttp://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.udla.catalogadorCBM
oaire.citation.endPage219
oaire.citation.issue2
oaire.citation.startPage215
oaire.citation.titlePOLISH JOURNAL OF MICROBIOLOGY
oaire.citation.volume72
oaire.fundingReference.awardNumber21191925
oaire.fundingReference.awardNumber1201805
oaire.fundingReference.awardNumber1212075
oaire.fundingReference.awardNumberECOS200037
oaire.fundingReference.awardNumber55008749
oaire.fundingReference.funderNameAgencia Nacional de Investigación y Desarrollo (ANID)
udla.curacion.controljmvg
udla.oecd.area1 Ciencias Naturales
udla.oecd.discipline1.6.2 Microbiología
udla.oecd.subarea1.6 Ciencias Biológicas

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