Molecular Analysis of Full-Length VP2 of Canine Parvovirus Reveals Antigenic Drift in CPV-2b and CPV-2c Variants in Central Chile

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dc.contributor.authorVéliz Ahumada, Alexis.
dc.contributor.authorVidal, Sonia
dc.contributor.authorSiel, Daniela
dc.contributor.authorGuzmán, Miguel
dc.contributor.authorHardaman, Timothy
dc.contributor.authorFarias, Valentina
dc.contributor.authorLapierre, Lisette
dc.contributor.authorSáenz, Leonardo
dc.date.accessioned2022-05-24T16:26:17Z
dc.date.available2022-05-24T16:26:17Z
dc.date.issued2021-08-12
dc.description.abstractCanine parvovirus (CPV) is a relevant pathogen, mainly affecting unvaccinated puppies, causing severe and fatal disease. CPV is classified into three variants (CPV-2a, CPV-2b and CPV-2c), which are widely distributed worldwide. These variants may be mutated at specific sites relevant to the immune response against CPV in dogs, and thus previously characterized vaccines may not be effective against new mutants. Therefore, the aim of the present study was to perform a molecular characterization of CPV variants. For this purpose, blood samples from canine patients in central Chile were used. The results of this study showed that the circulating variants were mainly CPV-2c followed by CPV-2b. In addition, genetic mutations were found in regions important for the immune response against CPV, which possibly has implications for the protective immunity generated by available vaccines.es
dc.facultadFacultad de Medicina Veterinaria y Agronomía
dc.format.extent11 páginas
dc.format.extent1.130Mb
dc.format.mimetypePDF
dc.identifier.citationAnimals, 11(8), 11 p.
dc.identifier.doihttps://doi.org/10.3390/ani11082387
dc.identifier.issn2076-2615
dc.identifier.urihttp://repositorio.udla.cl/xmlui/handle/udla/1040
dc.identifier.urihttps://www.mdpi.com/journal/animals
dc.language.isoenes
dc.publisherMDPI 
dc.rightsCreative Commons Attribution (CC BY)
dc.sourceAnimals
dc.subjectImmune escapees
dc.subjectAntigenic driftes
dc.subjectFull length VP2es
dc.subjectMolecular characterizationes
dc.subjectSelection pressureses
dc.subject.lcshCanine parvovirus.
dc.titleMolecular Analysis of Full-Length VP2 of Canine Parvovirus Reveals Antigenic Drift in CPV-2b and CPV-2c Variants in Central Chilees
dc.typeArtículoes
dc.udla.catalogadorCBM
dc.udla.indexSCOPUS
dc.udla.privacidadDocumento públicoes

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