Search for Novel Potent Inhibitors of the SARS-CoV-2 Papain-like Enzyme: A Computational Biochemistry Approach

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Date

2022-08-11

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journal article

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Investigación
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Authors

Osorio, Manuel I, Yáñez, Osvaldo, Gallardo, Mauricio, Zúñiga-Bustos, Matías, Mulia-Rodriguez, Jorge, Lopez-Rendon, Roberto, García-Beltrán, Olimpo, Gonzalez-Nilo, Fernando, Pérez-Donoso, José M.

Publisher

MDPI AG

URI

https://repositorio.udla.cl/handle/udla/1369

DOI

https://doi.org/10.3390/ph15080986

Keywords

papain-like protease of SARS-CoV-2, molecular dynamics simulation, binding free energy, virtual screening

Citation

Pharmaceuticals, 15(8), 986. https://doi.org/10.3390/ph15080986

Abstract

The rapid emergence and spread of new variants of coronavirus type 2, as well as the emergence of zoonotic viruses, highlights the need for methodologies that contribute to the search for new pharmaco...

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Creative Commons Attribution 4.0 International
Except where otherwised noted, this item's license is described as Creative Commons Attribution 4.0 International
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