Statins change the cytokine profile in Trypanosoma cruzi-infected U937 macrophages and murine cardiac tissue through Rho-associated kinases inhibition

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273.pdf (6.81 MB)

Date

2023

Document type

Artículo

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Investigación
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Authors

González Herrera, Fabiola., Clayton, Natasha S., Guzmán Rivera, Daniela., Carrillo, Ileana, Castillo, Christian, Catalán, Mabel, Anfossi, Renatto, Quintero Pertuz, Helena., Quilaqueo, María Elena, Olea Azar, Claudio., Rivera Meza, Mario., Kemmerling, Ulrike, Ridley, Anne J., Vivar, Raúl, Maya, Juan Diego

Faculty

Facultad de Medicina Veterinaria y Agronomía

Publisher

Frontiers Media

URI

http://repositorio.udla.cl/xmlui/handle/udla/1405, https://www.frontiersin.org/journals/immunology

DOI

10.3389/fimmu.2022.1035589

Keywords

Chronic chagas cardiomyopathy, Cytokine profile, Macrophage polarization, Rho-kinase

Citation

Frontiers in Immunology, 13, 16 p.

Extent

16 páginas
6.807Mb

Abstract

Introduction: Chronic Chagasic cardiomyopathy (CCC), caused by the protozoan Trypanosoma cruzi, is the most severe manifestation of Chagas disease.CCC is characterized by cardiac inflammation and fibr...

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