Statins change the cytokine profile in Trypanosoma cruzi-infected U937 macrophages and murine cardiac tissue through Rho-associated kinases inhibition

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Date

2023-01-11

Document type

journal article

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Investigación
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Authors

González-Herrera, Fabiola, Clayton, Natasha S., Guzman-Rivera, Daniela, Carrillo, Ileana, Castillo, Christian, Catalán, Mabel, Anfossi, Renatto, Quintero-Pertuz, Helena, Quilaqueo, Maria Elena, Olea-Azar, Claudio, Rivera-Meza, Mario, Kemmerling, Ulrike, Ridley, Anne J., Vivar, Raul, Maya, Juan Diego

Publisher

FRONTIERS MEDIA SA

URI

https://repositorio.udla.cl/handle/udla/1405

DOI

https://doi.org/10.3389/fimmu.2022.1035589

Keywords

chronic chagas cardiomyopathy, statins, rho-kinase, cytokine profile, macrophage polarization, Trypanosoma cruzi

Citation

Frontiers in Immunology, 13, 1035589. https://doi.org/10.3389/fimmu.2022.1035589

Abstract

Introduction Chronic Chagasic cardiomyopathy (CCC), caused by the protozoan Trypanosoma cruzi, is the most severe manifestation of Chagas disease.CCC is characterized by cardiac inflammation and fibro...

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Creative Commons Attribution 4.0 International
Except where otherwised noted, this item's license is described as Creative Commons Attribution 4.0 International
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