Genome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer's Disease

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Date

2022-06-30

Document type

journal article

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Investigación
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Authors

Hurley, Michael J., Urra, Claudio, Garduño, B. Maximiliano, Bruno, Agostino, Kimbell, Allison, Wilkinson, Brent, Marino-Buslje, Cristina, Ezquer, Marcelo, Ezquer, Fernando, Aburto, Pedro F., Poulin, Elie, Vasquez, Rodrigo A., Deacon, Robert, Ávila, Ariel, Altimiras, Francisco, Whitney Vanderklish, Peter, Zampieri, Guido, Angione, Claudio, Constantino, Gabriele, Holmes, Todd C., Coba, Marcelo P., Xu, Xiangmin, Cogram, Patricia

Publisher

FRONTIERS MEDIA SA

URI

https://repositorio.udla.cl/handle/udla/1371

DOI

https://doi.org/10.3389/fnagi.2022.894994

Keywords

Alzheimer's disease, aging, genome, APOE, amyloids, lipid droplets, Octodon degus, drug development

Citation

Frontiers in Aging Neuroscience, 14, 894994. https://doi.org/10.3389/fnagi.2022.894994

Abstract

The degu ( Octodon degus ) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age some degu, but not all individ...

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Creative Commons Attribution 4.0 International
Except where otherwised noted, this item's license is described as Creative Commons Attribution 4.0 International
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