Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging

Thumbnail Image

Files

161.pdf (2.83 MB)

Date

2025-11

Document type

journal article

Collections

Investigación
Total downloads0
Total views0
Bibliographic managers

Authors

Llanquinao-Sandoval, Jesús, Cicali, Karina A., Jara, Claudia, Vigil-Vásquez, Carlos, Sjöberg-Herrera, Marcela K., Ricca, Micaela, Valenzuela, Sebastian, Loyola, Alejandra, Pinti, Marcello, Schüller, Andreas, Kerr, Bredford, Tapia-Rojas, Cheril

Publisher

Nature Research

URI

https://repositorio.udla.cl/handle/udla/2314

DOI

https://doi.org/10.1038/s41598-025-24766-2

Keywords

Aging, Hippocampus, Epigenetics, Mecp2, Lonp1 1Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, 8580702 Santiago

Citation

Llanquinao-Sandoval, Jesús; Cicali, Karina A.; Jara, Claudia; Vigil-Vásquez, Carlos; Sjöberg-Herrera, Marcela K.; Ricca, Micaela; Valenzuela, Sebastian; Loyola, Alejandra; Pinti, Marcello; Schüller, Andreas; Kerr, Bredford; Tapia-Rojas, Cheril (2025). Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging. Scientific Reports, 15(1), 40887. https://doi.org/10.1038/s41598-025-24766-2

Abstract

Aging is characterized by a progressive decline in cellular function, including the hippocampus, a brain region crucial for learning and memory. Mitochondrial dysfunction is a hallmark of aging, criti...

Endorsement

Review

Supplemented By

Referenced By

Creative Commons license

Creative Commons Attribution 4.0 International
Except where otherwised noted, this item's license is described as Creative Commons Attribution 4.0 International
Usage statistics
01345
Feb 26Mar 26Apr 26May 26Jun 26Jul 26Aug 26