Screening of the antileishmanial and antiplasmodial potential of synthetic 2-arylquinoline analogs

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Date

2023-10-16

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journal article

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Investigación
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Authors

Espinosa-Saez, Roger, Robledo, Sara M., Pineda, Tatiana, Murillo, Javier, Zúñiga, César, Yanez, Osvaldo, Cantero-Lopez, Plinio, Saez-Vega, Alex, Guzman-Teran, Camilo

Publisher

Springer Science and Business Media LLC

URI

https://repositorio.udla.cl/handle/udla/1333

DOI

https://doi.org/10.1038/s41598-023-43805-4

Keywords

LIGAND EFFICIENCY INDEXES, DRUG DISCOVERY, IN-VITRO, PROTEIN, ANTIMALARIAL, DYNAMICS, DOCKING, STYRYLQUINOLINE, OPTIMIZATION, INTEGRATION

Citation

Scientific Reports, 13(1), 17523. https://doi.org/10.1038/s41598-023-43805-4

Abstract

Abstract In this study, six analogs of 2-arylquinoline were synthesized and evaluated for their in vitro and in vivo antiplasmodial and leishmanicidal activity. At a later stage, hemolytic activity an...

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Creative Commons Attribution 4.0 International
Except where otherwised noted, this item's license is described as Creative Commons Attribution 4.0 International
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