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Structural Characterization, DFT Calculation, NCI, Scan-Rate Analysis and Antifungal Activity against Botrytis cinerea of (E)-2-{[(2-Aminopyridin-2-yl)imino]-methyl}-4,6-di-tert-butylphenol (Pyridine Schiff Base)
dc.contributor.author | Autor | Carreño, Alexander | |
dc.contributor.author | Autor | Paez-Hernandez, Dayán. | |
dc.contributor.author | Autor | Cantero-López, Plinio. | |
dc.contributor.author | Autor | Zúñiga, César | |
dc.contributor.author | Autor | Nevermann, Jan | |
dc.contributor.author | Autor | Ramírez-Osorio, Angélica. | |
dc.contributor.author | Autor | Gacitúa, Manuel | |
dc.contributor.author | Autor | Oyarzún, Poldie | |
dc.contributor.author | Autor | Sáez-Cortez, Felipe. | |
dc.contributor.author | Autor | Polanco, Rubén | |
dc.contributor.author | Autor | Otero, Carolina | |
dc.contributor.author | Autor | Fuentes, Juan A. | |
dc.date.accessioned | Fecha ingreso | 2021-08-06T18:45:27Z | |
dc.date.available | Fecha disponible | 2021-08-06T18:45:27Z | |
dc.date.issued | Fecha publicación | 2020 | |
dc.identifier.citation | Referencia Bibliográfica | Molecules , 25(12), 24 p. | |
dc.identifier.issn | ISSN | 1420-3049 | |
dc.identifier.other | Código Control de Título | 103 | |
dc.identifier.uri | URL | https://www.mdpi.com/1420-3049/25/12/2741 | |
dc.identifier.uri | URL | http://repositorio.udla.cl/xmlui/handle/udla/910 | |
dc.description.abstract | Resumen | Botrytis cinerea is a ubiquitous necrotrophic filamentous fungal phytopathogen that lacks host specificity and can affect more than 1000 different plant species. In this work, we explored L1 [(E)-2-{[(2-aminopyridin-2-yl)imino]-methyl}-4,6-di-tert-butylphenol], a pyridine Schiff base harboring an intramolecular bond (IHB), regarding their antifungal activity against Botrytis cinerea. Moreover, we present a full characterization of the L1 by NMR and powder diffraction, as well as UV–vis, in the presence of previously untested different organic solvents. Complementary time-dependent density functional theory (TD-DFT) calculations were performed, and the noncovalent interaction (NCI) index was determined. Moreover, we obtained a scan-rate study on cyclic voltammetry of L1. Finally, we tested the antifungal activity of L1 against two strains of Botrytis cinerea (B05.10, a standard laboratory strain; and A1, a wild type strains isolated from Chilean blueberries). We found that L1 acts as an efficient antifungal agent against Botrytis cinerea at 26 °C, even better than the commercial antifungal agent fenhexamid. Although the antifungal activity was also observed at 4 °C, the effect was less pronounced. These results show the high versatility of this kind of pyridine Schiff bases in biological applications. | |
dc.format.extent | dc.format.extent | 24 páginas | |
dc.format.extent | dc.format.extent | 3,1 MB | |
dc.format.mimetype | dc.format.mimetype | ||
dc.language.iso | Lenguaje ISO | eng | |
dc.publisher | Editor | MDPI | |
dc.rights | Derechos | Atribución CC BY 4.0. | |
dc.source | Fuentes | Molecules | |
dc.subject | Palabras Claves | Pyridine Schiff base. | |
dc.subject | Palabras Claves | Intramolecular hydrogen bond. | |
dc.subject | Palabras Claves | Botrytis cinerea. | |
dc.title | Título | Structural Characterization, DFT Calculation, NCI, Scan-Rate Analysis and Antifungal Activity against Botrytis cinerea of (E)-2-{[(2-Aminopyridin-2-yl)imino]-methyl}-4,6-di-tert-butylphenol (Pyridine Schiff Base) | |
dc.type | Tipo de Documento | Artículo | |
dc.file.name | Nombre Archivo | 103.pdf | |
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dc.identifier.doi | dc.identifier.doi | https://doi.org/10.3390/molecules25122741 |