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dc.contributor.authorAuthorMartínez-Vizcaíno, Vicente.
dc.contributor.authorAuthorDíez-Fernández, Ana.
dc.contributor.authorAuthorÁlvarez-Bueno, Celia.
dc.contributor.authorAuthorMartínez-Alfonso, Julia.
dc.contributor.authorAuthorCavero-Redondo, Iván.
dc.contributor.otherCareerFacultad de Salud y Ciencias Sociales
dc.date.accessionedDate Accessioned2024-09-03T19:21:38Z
dc.date.availableDate Available2024-09-03T19:21:38Z
dc.date.issuedDate Issued2021
dc.identifier.citationReferencia BibliográficaJournal of Clinical Medicine, 10(12), 13 p.
dc.identifier.issnISSN2077-0383
dc.identifier.uriURIhttp://repositorio.udla.cl/xmlui/handle/udla/1659
dc.identifier.uriURIhttps://www.mdpi.com/journal/jcm
dc.description.abstractAbstractTo jointly assess the safety and effectiveness of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on cardiorenal outcomes and all-cause mortality in type 2 diabetes mellitus (T2DM) with or at high risk of cardiovascular disease (CVD). We performed a systematic review and network meta-analysis, systematically searching the MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Web of Science databases up to September 2020. Primary outcomes were composite major adverse cardiovascular events (MACEs), hospitalization for heart failure, all-cause mortality and a composite renal outcome. We performed a random effects network meta-analysis estimating the pooled hazard ratio (HR), risk ratio and number needed to treat (NNT). Six trials evaluating empagliflozin, canagliflozin, dapagliflozin and ertugliflozin met the inclusion/exclusion criteria, which comprised 46,969 patients, mostly with established CVD. Pooled estimates (95% CI) of benefits of SGLT2i in terms of HR and NNT were as follows: for all-cause mortality, 0.85 (0.75, 0.97) and 58 (28, 368); for MACE, 0.91 (0.85, 0.97) and 81 (44, 271); for hospitalization for heart failure, 0.70 (0.62, 0.78) and 32 (20, 55); and for composite renal outcome, 0.61 (0.50, 0.74) and 20 (11, 44). Pooled estimates for serious adverse events were 0.92 (95% CI 0.89, 0.95). In patients with T2DM at cardiovascular risk, ertugliflozin is a less potent drug than empagliflozin, canagliflozin or dapagliflozin to prevent cardiorenal events and all-cause mortality. In addition, our data endorse that empagliflozin is the best treatment option among SGLT2i for this type of patient, but the evidence is not consistent enough.
dc.format.extentdc.format.extent13 páginas
dc.format.extentdc.format.extent2.739Mb
dc.format.mimetypedc.format.mimetypePDF
dc.language.isoLanguage ISOeng
dc.publisherPublisherMDPI
dc.rightsRightsCreative Commons Attribution License (CC BY)
dc.sourceSourcesJournal of Clinical Medicine
dc.subjectSubjectEfficacy
dc.subjectSubjectSodium-glucose cotransporter 2 inhibitors
dc.subject.lcshdc.subject.lcshEfectos adversos
dc.subject.lcshdc.subject.lcshEnfermedades cardiovasculares
dc.subject.lcshdc.subject.lcshMeta-análisis
dc.titleTitleSafety and efficacy of sglt2 inhibitors: A multiple-treatment meta-analysis of clinical decision indicators
dc.typeDocument TypeArtículo de revisión
dc.udla.catalogadordc.udla.catalogadorCBM
dc.udla.indexdc.udla.indexWoS
dc.udla.indexdc.udla.indexScience Citation Index Expanded
dc.udla.indexdc.udla.indexScopus
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dc.udla.indexdc.udla.indexHealth Research Premium Collection
dc.identifier.doidc.identifier.doi10.3390/jcm10122713


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