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Variability of the genetic marker CLOCK rs3749474 and its impact on research and clinical trials on obesity and circadian rhythm
dc.contributor.author | Autor | Roco-Videla, Ángel | |
dc.contributor.author | Autor | Flores, Sergio V. | |
dc.contributor.author | Autor | Olguin-Barraza, Mariela | |
dc.contributor.author | Autor | Maureira-Carsalade, Nelson | |
dc.date.accessioned | Fecha ingreso | 2024-09-03T19:21:13Z | |
dc.date.available | Fecha disponible | 2024-09-03T19:21:13Z | |
dc.date.issued | Fecha publicación | 2022 | |
dc.identifier.citation | Referencia Bibliográfica | Nutrición Hospitalaria, 39(5), 5 p. | |
dc.identifier.issn | ISSN | 0212-1611 | |
dc.identifier.uri | URL | http://repositorio.udla.cl/xmlui/handle/udla/1611 | |
dc.identifier.uri | URL | https://www.nutricionhospitalaria.org/ | |
dc.description.abstract | Resumen | Introduction: circadian rhythms influence eating behavior, with the CLOCK gene being one of those responsible for its regulation. The rs3749474T/C of the CLOCK gene has been associated with an increased risk of obesity. Those who carry the T allele have greater weight loss on a diet low in carbohydrates and lipids than those who have the CC form. Methodology: using the 1000 Genomes database, the genotype of the single nucleotide polymorphism (SNP) rs3749474 was obtained from 2,504 individuals, covering five macro-populations (Africa, East Asia, South Asia, Europe and Latin America) and 26 populations. CT and TT were treated as non-risk genotypes and CC as risk. Fisher’s exact test was used to compare the frequencies of risk and non-risk genotypes among the five macro populations. Results: there is a high differentiation for the frequency of genotypes carrying the T allele among the macro-populations: Africa reached only 31.47 %, Europe 56.86 %; Latin America 66.28 %; South Asia 68.3 % and East Asia 81.15 %, with significant differences (pFisher < 0.05) in all comparisons, except between Latin America and South Asia. Low heterogeneity was observed between populations within each macro population. Conclusions: the high heterogeneity for the genotypic frequencies of CLOCK rs3749474 in the studied macro-populations indicates that the decrease in the consumption of carbohydrates and lipids will have a heterogeneous impact, from the epidemiological point of view. This sug-gests including the genetic ancestry in later studies of association between circadian cycles, eating behavior and obesity, in order to develop personalized clinical tests. | |
dc.format.extent | dc.format.extent | 5 páginas | |
dc.format.extent | dc.format.extent | 843.4Kb | |
dc.format.mimetype | dc.format.mimetype | ||
dc.language.iso | Lenguaje ISO | spa | |
dc.publisher | Editor | ARAN Ediciones | |
dc.rights | Derechos | Creative Commons Atribución-NoComercial-CompartirIgual (CC BY-NC-SA) | |
dc.source | Fuentes | Nutricion Hospitalaria | |
dc.subject | Palabras Claves | CLOCK gene | |
dc.subject | Palabras Claves | rs3749474 | |
dc.subject.lcsh | dc.subject.lcsh | Ritmo circadiano | |
dc.subject.lcsh | dc.subject.lcsh | Obesidad | |
dc.title | Título | Variability of the genetic marker CLOCK rs3749474 and its impact on research and clinical trials on obesity and circadian rhythm | |
dc.title.alternative | Título Alternativo | Variabilidad del marcador genético CLOCK rs3749474 y su impacto en investigaciones y pruebas clínicas sobre obesidad y ritmo circadiano | |
dc.type | Tipo de Documento | Artículo | |
dc.udla.catalogador | dc.udla.catalogador | CBM | |
dc.udla.index | dc.udla.index | WoS | |
dc.udla.index | dc.udla.index | Science Citation Index Expanded | |
dc.udla.index | dc.udla.index | Scopus | |
dc.udla.index | dc.udla.index | Academic Search Ultimate | |
dc.udla.index | dc.udla.index | Fuente Academica Plus | |
dc.udla.index | dc.udla.index | DIALNET | |
dc.udla.index | dc.udla.index | DOAJ | |
dc.udla.index | dc.udla.index | Biomedical Reference Collection: Corporate Edition | |
dc.udla.index | dc.udla.index | CINAHL | |
dc.udla.index | dc.udla.index | EMBASE | |
dc.udla.index | dc.udla.index | MEDLINE | |
dc.identifier.doi | dc.identifier.doi | 10.20960/nh.04230 | |
dc.facultad | dc.facultad | Facultad de Salud y Ciencias Sociales |