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dc.contributor.authorAuthorRoco-Videla, Ángel
dc.contributor.authorAuthorFlores, Sergio V.
dc.contributor.authorAuthorOlguin-Barraza, Mariela
dc.contributor.authorAuthorMaureira-Carsalade, Nelson
dc.date.accessionedDate Accessioned2024-09-03T19:21:13Z
dc.date.availableDate Available2024-09-03T19:21:13Z
dc.date.issuedDate Issued2022
dc.identifier.citationReferencia BibliográficaNutrición Hospitalaria, 39(5), 5 p.
dc.identifier.issnISSN0212-1611
dc.identifier.uriURIhttp://repositorio.udla.cl/xmlui/handle/udla/1611
dc.identifier.uriURIhttps://www.nutricionhospitalaria.org/
dc.description.abstractAbstractIntroduction: circadian rhythms influence eating behavior, with the CLOCK gene being one of those responsible for its regulation. The rs3749474T/C of the CLOCK gene has been associated with an increased risk of obesity. Those who carry the T allele have greater weight loss on a diet low in carbohydrates and lipids than those who have the CC form. Methodology: using the 1000 Genomes database, the genotype of the single nucleotide polymorphism (SNP) rs3749474 was obtained from 2,504 individuals, covering five macro-populations (Africa, East Asia, South Asia, Europe and Latin America) and 26 populations. CT and TT were treated as non-risk genotypes and CC as risk. Fisher’s exact test was used to compare the frequencies of risk and non-risk genotypes among the five macro populations. Results: there is a high differentiation for the frequency of genotypes carrying the T allele among the macro-populations: Africa reached only 31.47 %, Europe 56.86 %; Latin America 66.28 %; South Asia 68.3 % and East Asia 81.15 %, with significant differences (pFisher < 0.05) in all comparisons, except between Latin America and South Asia. Low heterogeneity was observed between populations within each macro population. Conclusions: the high heterogeneity for the genotypic frequencies of CLOCK rs3749474 in the studied macro-populations indicates that the decrease in the consumption of carbohydrates and lipids will have a heterogeneous impact, from the epidemiological point of view. This sug-gests including the genetic ancestry in later studies of association between circadian cycles, eating behavior and obesity, in order to develop personalized clinical tests.
dc.format.extentdc.format.extent5 páginas
dc.format.extentdc.format.extent843.4Kb
dc.format.mimetypedc.format.mimetypePDF
dc.language.isoLanguage ISOspa
dc.publisherPublisherARAN Ediciones
dc.rightsRightsCreative Commons Atribución-NoComercial-CompartirIgual (CC BY-NC-SA)
dc.sourceSourcesNutricion Hospitalaria
dc.subjectSubjectCLOCK gene
dc.subjectSubjectrs3749474
dc.subject.lcshdc.subject.lcshRitmo circadiano
dc.subject.lcshdc.subject.lcshObesidad
dc.titleTitleVariability of the genetic marker CLOCK rs3749474 and its impact on research and clinical trials on obesity and circadian rhythm
dc.title.alternativeAlternative TitleVariabilidad del marcador genético CLOCK rs3749474 y su impacto en investigaciones y pruebas clínicas sobre obesidad y ritmo circadiano
dc.typeDocument TypeArtículo
dc.udla.catalogadordc.udla.catalogadorCBM
dc.udla.indexdc.udla.indexWoS
dc.udla.indexdc.udla.indexScience Citation Index Expanded
dc.udla.indexdc.udla.indexScopus
dc.udla.indexdc.udla.indexAcademic Search Ultimate
dc.udla.indexdc.udla.indexFuente Academica Plus
dc.udla.indexdc.udla.indexDIALNET
dc.udla.indexdc.udla.indexDOAJ
dc.udla.indexdc.udla.indexBiomedical Reference Collection: Corporate Edition
dc.udla.indexdc.udla.indexCINAHL
dc.udla.indexdc.udla.indexEMBASE
dc.udla.indexdc.udla.indexMEDLINE
dc.identifier.doidc.identifier.doi10.20960/nh.04230
dc.facultaddc.facultadFacultad de Salud y Ciencias Sociales


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