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dc.contributor.authorAuthorRojas-Pirela, Maura
dc.contributor.authorAuthorAndrade-Alviárez, Diego
dc.contributor.authorAuthorMedina, Lisvaneth
dc.contributor.authorAuthorCastillo, Christian
dc.contributor.authorAuthorLiempi, Ana
dc.contributor.authorAuthorGuerrero-Muñoz, Jesús
dc.contributor.authorAuthorOrtega , Yessica
dc.contributor.authorAuthorMaya, Juan Diego
dc.contributor.authorAuthorRojas, Verónica
dc.contributor.authorAuthorQuiñones, Wilfredo
dc.contributor.authorAuthorMichels, Paul A.
dc.contributor.authorAuthorKemmerling, Ulrike
dc.date.accessionedDate Accessioned2024-09-03T19:19:18Z
dc.date.availableDate Available2024-09-03T19:19:18Z
dc.date.issuedDate Issued2022
dc.identifier.citationReferencia BibliográficaOpen Biology, 12(6), 25 p.
dc.identifier.issnISSN2046-2441
dc.identifier.uriURIhttp://repositorio.udla.cl/xmlui/handle/udla/1449
dc.identifier.uriURIhttps://royalsocietypublishing.org/journal/rsob
dc.description.abstractAbstractMicroRNAs (miRNAs) are a group of small non-coding RNAs present in a wide diversity of organisms. MiRNAs regulate gene expression at a post-transcriptional level through their interaction with the 3′ untranslated regions of target mRNAs, inducing translational inhibition or mRNA destabilization and degradation. Thus, miRNAs regulate key biological processes, such as cell death, signal transduction, development, cellular proliferation and differentiation. The dysregulation of miRNAs biogenesis and function is related to the pathogenesis of diseases, including parasite infection. Moreover, during host-parasite interactions, parasites and host miRNAs determine the probability of infection and progression of the disease. The present review is focused on the possible role of miRNAs in the pathogenesis of diseases of clinical interest caused by parasitic protists. In addition, the potential role of miRNAs as targets for the design of drugs and diagnostic and prognostic markers of parasitic diseases is also discussed.
dc.format.extentdc.format.extent25 páginas
dc.format.extentdc.format.extent3.412Mb
dc.format.mimetypedc.format.mimetypePDF
dc.language.isoLanguage ISOeng
dc.publisherPublisherRoyal Society Publishing
dc.rightsRightsCreative Commons Attribution License (CC BY)
dc.sourceSourcesOpen Biology
dc.subjectSubjectApicomplexan
dc.subjectSubjectDiagnostic and therapeutic tools
dc.subjectSubjectKinetoplastids
dc.subject.lcshdc.subject.lcshApicomplexa
dc.subject.lcshdc.subject.lcshMicroRNA
dc.subject.meshdc.subject.meshHost-Parasite Interactions
dc.titleTitleMicroRNAs: Master regulators in host-parasitic protist interactions
dc.typeDocument TypeArtículo de revisión
dc.udla.catalogadordc.udla.catalogadorCBM
dc.udla.indexdc.udla.indexWoS
dc.udla.indexdc.udla.indexScience Citation Index Expanded
dc.udla.indexdc.udla.indexScopus
dc.udla.indexdc.udla.indexNatural Science Collection
dc.udla.indexdc.udla.indexDOAJ
dc.udla.indexdc.udla.indexBiological Science Database
dc.udla.indexdc.udla.indexBIOSIS
dc.udla.indexdc.udla.indexCAB Abstracts
dc.udla.indexdc.udla.indexMEDLINE
dc.identifier.doidc.identifier.doi10.1098/rsob.210395
dc.facultaddc.facultadFacultad de Medicina Veterinaria y Agronomía


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