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dc.contributor.authorAutorBarrera-Avalos, Carlos
dc.contributor.authorAutorMena, Javier
dc.contributor.authorAutorLuraschi, Roberto
dc.contributor.authorAutorRojas, Patricio
dc.contributor.authorAutorMateluna-Flores, Carlos
dc.contributor.authorAutorVallejos-Vidal, Eva
dc.contributor.authorAutorImarai, Mónica
dc.contributor.authorAutorSandino, Ana María
dc.contributor.authorAutorValdés, Daniel
dc.contributor.authorAutorVera, Rodrigo
dc.contributor.authorAutorHernández, Iván
dc.contributor.authorAutorReyes-López, Felipe E.
dc.contributor.authorAutorAcuña-Castillo, Claudio
dc.date.accessionedFecha ingreso2024-09-03T19:19:14Z
dc.date.availableFecha disponible2024-09-03T19:19:14Z
dc.date.issuedFecha publicación2022
dc.identifier.citationReferencia BibliográficaFrontiers in Public Health, 10, 9 p.
dc.identifier.issnISSN2296-2565
dc.identifier.uriURLhttp://repositorio.udla.cl/xmlui/handle/udla/1437
dc.identifier.uriURLhttps://www.frontiersin.org/journals/public-health
dc.description.abstractResumenThe COVID-19 pandemic continues to be a concern and keeps global health authorities on alert. The RT-PCR technique has been the gold-standard assay for detecting the SARS-CoV-2 virus. However, rapid antigen tests (RATs) have been widely used to increase the number of tests faster and more efficiently in the population. Nevertheless, the appearance of new viral variants, with genomic mutations associated with greater contagiousness and immune evasion, highlights the need to evaluate the sensitivity of these RATs. This report evaluates the sensitivity of SD Biosensor-Roche, Panbio™, and Clinitest® RATs widely used in Santiago de Chile in the detection of the Omicron variant from Nasopharyngeal samples (NPSs), the most predominant SARS-CoV-2 variant in Chile and the world. SD Biosensor-Roche shows a detection sensitivity of 95.7% in the viral amplification range of 20 ≤ Cq < 25, while Panbio™ and Clinitest® show 100% and 91.3%, respectively. In the viral amplification ranges of 25 ≤ Cq < 30, the detection sensitivity decreased to 28% for SD Biosensor-Roche, 32% for Panbio™, and 72% for Clinitest®. This study indicates that the tested RATs have high sensitivity in detecting the Omicron variant of concern (VOC) at high viral loads. By contrast, its sensitivity decreases at low viral loads. Therefore, it is suggested to limit the use of RATs as an active search method, considering that infections in patients are increasingly associated with lower viral loads of SARS-CoV-2. These antecedents could prevent contagion outbreaks and reduce the underestimation of the current Omicron variant circulation at the local level.
dc.format.extentdc.format.extent9 páginas
dc.format.extentdc.format.extent2.884Mb
dc.format.mimetypedc.format.mimetypePDF
dc.language.isoLenguaje ISOeng
dc.publisherEditorFrontiers Media
dc.rightsDerechosCreative Commons Attribution License (CC BY)
dc.sourceFuentesFrontiers in Public Health
dc.subjectPalabras ClavesDetection sensitivity
dc.subjectPalabras ClavesOmicron detection
dc.subjectPalabras ClavesRapid antigen test - RT-Qpcr
dc.subjectPalabras ClavesSARS-CoV-2
dc.subject.lcshdc.subject.lcshCOVID-19 (Enfermedad)
dc.subject.lcshdc.subject.lcshCOVID-19 pandemia, 2020- Chile
dc.titleTítuloSensitivity analysis of rapid antigen tests for the Omicron SARS-CoV-2 variant detection from nasopharyngeal swab samples collected in Santiago of Chile
dc.typeTipo de DocumentoArtículo
dc.udla.catalogadordc.udla.catalogadorCBM
dc.udla.indexdc.udla.indexWoS
dc.udla.indexdc.udla.indexScience Citation Index Expanded
dc.udla.indexdc.udla.indexScopus
dc.udla.indexdc.udla.indexSocial Sciences Citation Index
dc.udla.indexdc.udla.indexDOAJ
dc.udla.indexdc.udla.indexEMBASE
dc.udla.indexdc.udla.indexMEDLINE
dc.udla.indexdc.udla.indexPsycinfo
dc.identifier.doidc.identifier.doi10.3389/fpubh.2022.976875
dc.facultaddc.facultadFacultad de Medicina Veterinaria y Agronomía


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