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dc.contributor.authorAuthorHurley M.J.
dc.contributor.authorAuthorUrra, Claudio
dc.contributor.authorAuthorGarduno, Maximiliano
dc.contributor.authorAuthorBruno, Agostino
dc.contributor.authorAuthorKimbell, Allison
dc.contributor.authorAuthorWilkinson, Brent
dc.contributor.authorAuthorMarino-Buslje, Cristina
dc.contributor.authorAuthorEzquer, Marcelo
dc.contributor.authorAuthorEzquer, Fernando
dc.contributor.authorAuthorAburto, Pedro F.
dc.contributor.authorAuthorPoulin, Elie
dc.contributor.authorAuthorVasquez, Rodrigo A.
dc.contributor.authorAuthorDeacon, Robert
dc.contributor.authorAuthorAvila, Ariel
dc.contributor.authorAuthorAltimiras, Francisco
dc.contributor.authorAuthorVanderklish, Peter Whitney
dc.contributor.authorAuthorZampieri, Guido
dc.contributor.authorAuthorAngione, Claudio
dc.contributor.authorAuthorConstantino, Gabriele
dc.contributor.authorAuthorHolmes, Todd C.
dc.contributor.authorAuthorCoba, Marcelo P.
dc.contributor.authorAuthorXu, Xiangmin
dc.contributor.authorAuthorCogram, Patricia
dc.date.accessionedDate Accessioned2024-09-03T19:17:49Z
dc.date.availableDate Available2024-09-03T19:17:49Z
dc.date.issuedDate Issued2022
dc.identifier.citationReferencia BibliográficaFrontiers in Aging Neuroscience, 14,16 p.
dc.identifier.issnISSN1663-4365
dc.identifier.uriURIhttp://repositorio.udla.cl/xmlui/handle/udla/1371
dc.identifier.uriURIhttps://www.frontiersin.org/journals/aging-neuroscience
dc.description.abstractAbstractThe degu (Octodon degus) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age some degu, but not all individuals, develop cognitive decline and brain pathology like that observed in Alzheimer's disease including neuroinflammation, hyperphosphorylated tau and amyloid plaques, together with other co-morbidities associated with aging such as macular degeneration, cataracts, alterations in circadian rhythm, diabetes and atherosclerosis. Here we report the whole-genome sequencing and analysis of the degu genome, which revealed unique features and molecular adaptations consistent with aging and Alzheimer's disease. We identified single nucleotide polymorphisms in genes associated with Alzheimer's disease including a novel apolipoprotein E (Apoe) gene variant that correlated with an increase in amyloid plaques in brain and modified the in silico predicted degu APOE protein structure and functionality. The reported genome of an unconventional long-lived animal model of aging and Alzheimer's disease offers the opportunity for understanding molecular pathways involved in aging and should help advance biomedical research into treatments for Alzheimer's disease.
dc.format.extentdc.format.extent16 páginas
dc.format.extentdc.format.extent4.355Mb
dc.format.mimetypedc.format.mimetypePDF
dc.language.isoLanguage ISOeng
dc.publisherPublisherFrontiers Media
dc.sourceSourcesFrontiers in Aging Neuroscience
dc.subjectSubjectAmyloids
dc.subjectSubjectAPOE
dc.subjectSubjectLipid droplets
dc.subjectSubjectOctodon degus
dc.subject.lcshdc.subject.lcshEnvejecimiento
dc.subject.lcshdc.subject.lcshEnfermedad de Alzheimer
dc.subject.lcshdc.subject.lcshDesarrollo de drogas
dc.subject.lcshdc.subject.lcshGenomas
dc.titleTitleGenome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer''s Disease
dc.typeDocument TypeArtículo
dc.udla.catalogadordc.udla.catalogadorCBM
dc.udla.indexdc.udla.indexWoS
dc.udla.indexdc.udla.indexScience Citation Index Expanded
dc.udla.indexdc.udla.indexScopus
dc.udla.indexdc.udla.indexNatural Science Collection
dc.udla.indexdc.udla.indexDOAJ
dc.udla.indexdc.udla.indexAgeLine
dc.udla.indexdc.udla.indexBiological Science Database
dc.udla.indexdc.udla.indexBIOSIS
dc.udla.indexdc.udla.indexCINAHL
dc.udla.indexdc.udla.indexEMBASE
dc.udla.indexdc.udla.indexHealth Research Premium Collection
dc.udla.indexdc.udla.indexRILM Abstracts of Music Literature
dc.udla.indexdc.udla.indexPsycinfo
dc.identifier.doidc.identifier.doi10.3389/fnagi.2022.894994
dc.facultaddc.facultadFacultad de Ingeniería y Negocios


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