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dc.contributor.authorAuthorBruna, Flavia
dc.contributor.authorAuthorFernández, Katia
dc.contributor.authorAuthorUrrejola, Felipe
dc.contributor.authorAuthorTouma, Jorge
dc.contributor.authorAuthorNavarro, Myriam
dc.contributor.authorAuthorSepúlveda, Betsabet
dc.contributor.authorAuthorLarrazabal-Fuentes, María
dc.contributor.authorAuthorParedes, Adrián
dc.contributor.authorAuthorNeira, Iván
dc.contributor.authorAuthorFerrando, Matías
dc.contributor.authorAuthorOsorio, Manuel
dc.contributor.authorAuthorYáñez, Osvaldo
dc.contributor.authorAuthorBravo, Jessica
dc.date.accessionedDate Accessioned2024-09-03T19:17:47Z
dc.date.availableDate Available2024-09-03T19:17:47Z
dc.date.issuedDate Issued2022
dc.identifier.citationReferencia BibliográficaArabian Journal of Chemistry, 15(12), 16 p.
dc.identifier.issnISSN1878-5352
dc.identifier.uriURIhttp://repositorio.udla.cl/xmlui/handle/udla/1364
dc.identifier.uriURIhttps://www.sciencedirect.com/journal/arabian-journal-of-chemistry
dc.description.abstractAbstractChilean Laureliopsis philippiana has been used in traditional medicine by the Mapuche and their ancestors. To evaluate its pharmacological activity, Laureliopsis philippiana leaf essential oil extract (LP_EO) was chemically and biologically characterized in the present study. In vitro antioxidant potential was analyzed, and antitumor activity was evaluated in non-tumor and tumor cell culture lines. Caenorhabditis elegans was used as a model for evaluating toxicity, and the chemical composition of the essential oil was analyzed using gas chromatography–mass spectrometry. The oil contains six major monoterpenes: eucalyptol (27.7 %), linalool (27.6 %), isozaphrol (19.5 %), isohomogenol (12.6 %), α-terpineol (7.7 %), and eudesmol (4.8 %). Based on quantum mechanical calculations, isosafrole and isohomogenol conferred in vitro antioxidant and antimicrobial activity to LP_EO. In addition, LP_EO showed antimicrobial activity against clinical Helicobacter pylori isolates (MIC 64 and MBC > 128 μg·mL−1), Staphylococcus aureus (MIC 32 and MBC > 64 μg·mL−1), Escherichia coli (MIC 8 and MBC 16 μg·mL−1) and Candida albicans (MIC 64 and > 128 μg·mL−1). LP_EO could selectively inhibit the proliferation of epithelial tumor cell lines but showed low toxicity against Caenorhabditis elegans (0.39 to 1.56 μg·mL−1). Therefore, LP_EO may be used as a source of bioactive compounds in novel pharmacological treatments for veterinary and human application, cosmetics, or sanitation.
dc.format.extentdc.format.extent16 páginas
dc.format.extentdc.format.extent1,75 MB
dc.format.mimetypedc.format.mimetypePDF
dc.language.isoLanguage ISOeng
dc.publisherPublisherElsevier
dc.rightsRightsCreative Commons: Atribución-NoComercial-NoDerivadas (CC BY-NC-ND)
dc.sourceSourcesArabian Journal of Chemistry
dc.subjectSubjectAICAR
dc.subjectSubjectDerivative
dc.subjectSubjectAMPK
dc.subject.lcshdc.subject.lcshFatiga
dc.titleTitleChemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silico
dc.typeDocument TypeArtículo
dc.udla.catalogadordc.udla.catalogadorCBM
dc.udla.indexdc.udla.indexWoS
dc.udla.indexdc.udla.indexScience Citation Index Expanded
dc.udla.indexdc.udla.indexScopus
dc.udla.indexdc.udla.indexDOAJ
dc.udla.indexdc.udla.indexCompendex
dc.udla.indexdc.udla.indexINSPEC
dc.identifier.doidc.identifier.doi10.1016/j.arabjc.2022.104271
dc.facultaddc.facultadFacultad de Ingeniería y Negocios


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