dc.contributor.author | Author | Bruna, Flavia | |
dc.contributor.author | Author | Fernández, Katia | |
dc.contributor.author | Author | Urrejola, Felipe | |
dc.contributor.author | Author | Touma, Jorge | |
dc.contributor.author | Author | Navarro, Myriam | |
dc.contributor.author | Author | Sepúlveda, Betsabet | |
dc.contributor.author | Author | Larrazabal-Fuentes, María | |
dc.contributor.author | Author | Paredes, Adrián | |
dc.contributor.author | Author | Neira, Iván | |
dc.contributor.author | Author | Ferrando, Matías | |
dc.contributor.author | Author | Osorio, Manuel | |
dc.contributor.author | Author | Yáñez, Osvaldo | |
dc.contributor.author | Author | Bravo, Jessica | |
dc.date.accessioned | Date Accessioned | 2024-09-03T19:17:47Z | |
dc.date.available | Date Available | 2024-09-03T19:17:47Z | |
dc.date.issued | Date Issued | 2022 | |
dc.identifier.citation | Referencia Bibliográfica | Arabian Journal of Chemistry, 15(12), 16 p. | |
dc.identifier.issn | ISSN | 1878-5352 | |
dc.identifier.uri | URI | http://repositorio.udla.cl/xmlui/handle/udla/1364 | |
dc.identifier.uri | URI | https://www.sciencedirect.com/journal/arabian-journal-of-chemistry | |
dc.description.abstract | Abstract | Chilean Laureliopsis philippiana has been used in traditional medicine by the Mapuche and their ancestors. To evaluate its pharmacological activity, Laureliopsis philippiana leaf essential oil extract (LP_EO) was chemically and biologically characterized in the present study. In vitro antioxidant potential was analyzed, and antitumor activity was evaluated in non-tumor and tumor cell culture lines. Caenorhabditis elegans was used as a model for evaluating toxicity, and the chemical composition of the essential oil was analyzed using gas chromatography–mass spectrometry. The oil contains six major monoterpenes: eucalyptol (27.7 %), linalool (27.6 %), isozaphrol (19.5 %), isohomogenol (12.6 %), α-terpineol (7.7 %), and eudesmol (4.8 %). Based on quantum mechanical calculations, isosafrole and isohomogenol conferred in vitro antioxidant and antimicrobial activity to LP_EO. In addition, LP_EO showed antimicrobial activity against clinical Helicobacter pylori isolates (MIC 64 and MBC > 128 μg·mL−1), Staphylococcus aureus (MIC 32 and MBC > 64 μg·mL−1), Escherichia coli (MIC 8 and MBC 16 μg·mL−1) and Candida albicans (MIC 64 and > 128 μg·mL−1). LP_EO could selectively inhibit the proliferation of epithelial tumor cell lines but showed low toxicity against Caenorhabditis elegans (0.39 to 1.56 μg·mL−1). Therefore, LP_EO may be used as a source of bioactive compounds in novel pharmacological treatments for veterinary and human application, cosmetics, or sanitation. | |
dc.format.extent | dc.format.extent | 16 páginas | |
dc.format.extent | dc.format.extent | 1,75 MB | |
dc.format.mimetype | dc.format.mimetype | PDF | |
dc.language.iso | Language ISO | eng | |
dc.publisher | Publisher | Elsevier | |
dc.rights | Rights | Creative Commons: Atribución-NoComercial-NoDerivadas (CC BY-NC-ND) | |
dc.source | Sources | Arabian Journal of Chemistry | |
dc.subject | Subject | AICAR | |
dc.subject | Subject | Derivative | |
dc.subject | Subject | AMPK | |
dc.subject.lcsh | dc.subject.lcsh | Fatiga | |
dc.title | Title | Chemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silico | |
dc.type | Document Type | Artículo | |
dc.udla.catalogador | dc.udla.catalogador | CBM | |
dc.udla.index | dc.udla.index | WoS | |
dc.udla.index | dc.udla.index | Science Citation Index Expanded | |
dc.udla.index | dc.udla.index | Scopus | |
dc.udla.index | dc.udla.index | DOAJ | |
dc.udla.index | dc.udla.index | Compendex | |
dc.udla.index | dc.udla.index | INSPEC | |
dc.identifier.doi | dc.identifier.doi | 10.1016/j.arabjc.2022.104271 | |
dc.facultad | dc.facultad | Facultad de Ingeniería y Negocios | |