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dc.contributor.authorAuthorPérez-Jeldres, Tamara
dc.contributor.authorAuthorMagne, Fabien
dc.contributor.authorAuthorAscui, Gabriel
dc.contributor.authorAuthorAlvares, Danilo
dc.contributor.authorAuthorOrellana, Matias
dc.contributor.authorAuthorAlvarez-Lobos, Manuel
dc.contributor.authorAuthorHernandez-Rocha, Cristian
dc.contributor.authorAuthorAzocar, Lorena
dc.contributor.authorAuthorAguilar, Nataly
dc.contributor.authorAuthorEspino, Alberto
dc.contributor.authorAuthorEstela, Ricardo
dc.contributor.authorAuthorEscobar, Sergio
dc.contributor.authorAuthorZazueta, Alejandra
dc.contributor.authorAuthorBaez, Pablo
dc.contributor.authorAuthorSilva, Verónica
dc.contributor.authorAuthorVega, Andres De La
dc.contributor.authorAuthorArriagada, Elizabeth
dc.contributor.authorAuthorPavez-Ovalle, Carolina
dc.contributor.authorAuthorDíaz-Asencio, Alejandro
dc.contributor.authorAuthorTravisany, Dante
dc.contributor.authorAuthorMiquel, Juan Francisco
dc.contributor.authorAuthorVillablanca, Eduardo J.
dc.contributor.authorAuthorKronenberg, Mitchell
dc.contributor.authorAuthorBustamante, María Leonor
dc.date.accessionedDate Accessioned2024-09-03T19:17:45Z
dc.date.availableDate Available2024-09-03T19:17:45Z
dc.date.issuedDate Issued2023
dc.identifier.citationReferencia BibliográficaFrontiers in Medicine, 10, 12 p.
dc.identifier.issnISSN2296-858X
dc.identifier.uriURIhttp://repositorio.udla.cl/xmlui/handle/udla/1356
dc.identifier.uriURIhttps://www.frontiersin.org/journals/medicine
dc.description.abstractAbstractBackground and aims: Latin American populations remain underrepresented in genetic studies of inflammatory bowel diseases (IBDs). Most genetic association studies of IBD rely on Caucasian, African, and Asian individuals. These associations have yet to be evaluated in detail in the Andean region of South America. We explored the contribution of IBD-reported genetic risk variants to a Chilean cohort and the ancestry contribution to IBD in this cohort. Methods: A total of 192 Chilean IBD patients were genotyped using Illumina's Global Screening Array. Genotype data were combined with similar information from 3,147 Chilean controls. The proportions of Aymara, African, European, and Mapuche ancestries were estimated using the software ADMIXTURE. We calculated the odds ratios (ORs) and 95% confidence intervals (CIs) for gender, age, and ancestry proportions. We also explored associations with previously reported IBD-risk variants independently and in conjunction with genetic ancestry. Results: The first and third quartiles of the proportion of Mapuche ancestry in IBD patients were 24.7 and 34.2%, respectively, and the corresponding OR was 2.30 (95%CI 1.52–3.48) for the lowest vs. the highest group. Only one variant (rs7210086) of the 180 reported IBD-risk SNPs was associated with IBD risk in the Chilean cohort (adjusted P = 0.01). This variant is related to myeloid cells. Conclusion: The type and proportion of Native American ancestry in Chileans seem to be associated with IBD risk. Variants associated with IBD risk in this Andean region were related to myeloid cells and the innate immune response.
dc.format.extentdc.format.extent12 páginas
dc.format.extentdc.format.extent897.5Kb
dc.format.mimetypedc.format.mimetypePDF
dc.language.isoLanguage ISOeng
dc.publisherPublisherFrontiers Media SA
dc.rightsRightsCreative Commons Attribution License (CC BY)
dc.sourceSourcesFrontiers in Medicine
dc.subjectSubjectSingle nucleotide polymorphism (SNP)
dc.subject.lcshdc.subject.lcshEnfermedades inflamatorias del intestino
dc.subject.lcshdc.subject.lcshAscendencia
dc.subject.lcshdc.subject.lcshAmérica Latina
dc.subject.lcshdc.subject.lcshGenética
dc.titleTitleAmerindian ancestry proportion as a risk factor for inflammatory bowel diseases: results from a Latin American Andean cohort
dc.typeDocument TypeArtículo
dc.udla.catalogadordc.udla.catalogadorCBM
dc.udla.indexdc.udla.indexScience Citation Index Expanded
dc.udla.indexdc.udla.indexScopus
dc.udla.indexdc.udla.indexDOAJ
dc.udla.indexdc.udla.indexEMBASE
dc.identifier.doidc.identifier.doi10.3389/fmed.2023.1258395
dc.facultaddc.facultadFacultad de Ingeniería y Negocios


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