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dc.contributor.authorAutorAmaya-Rodriguez, Cesar A.
dc.contributor.authorAutorCarvajal-Zamorano, Karina.
dc.contributor.authorAutorBustos, Daniel
dc.contributor.authorAutorAlegría-Arcos, Melissa.
dc.contributor.authorAutorCastillo, Karen
dc.date.accessionedFecha ingreso2024-09-03T19:17:44Z
dc.date.availableFecha disponible2024-09-03T19:17:44Z
dc.date.issuedFecha publicación2023
dc.identifier.citationReferencia BibliográficaFrontiers in Pharmacology, 14, 26 p.
dc.identifier.issnISSN1663-9812
dc.identifier.uriURLhttp://repositorio.udla.cl/xmlui/handle/udla/1354
dc.identifier.uriURLhttps://www.frontiersin.org/journals/pharmacology
dc.description.abstractResumenThe heat and capsaicin receptor TRPV1 channel is widely expressed in nerve terminals of dorsal root ganglia (DRGs) and trigeminal ganglia innervating the body and face, respectively, as well as in other tissues and organs including central nervous system. The TRPV1 channel is a versatile receptor that detects harmful heat, pain, and various internal and external ligands. Hence, it operates as a polymodal sensory channel. Many pathological conditions including neuroinflammation, cancer, psychiatric disorders, and pathological pain, are linked to the abnormal functioning of the TRPV1 in peripheral tissues. Intense biomedical research is underway to discover compounds that can modulate the channel and provide pain relief. The molecular mechanisms underlying temperature sensing remain largely unknown, although they are closely linked to pain transduction. Prolonged exposure to capsaicin generates analgesia, hence numerous capsaicin analogs have been developed to discover efficient analgesics for pain relief. The emergence of in silico tools offered significant techniques for molecular modeling and machine learning algorithms to indentify druggable sites in the channel and for repositioning of current drugs aimed at TRPV1. Here we recapitulate the physiological and pathophysiological functions of the TRPV1 channel, including structural models obtained through cryo-EM, pharmacological compounds tested on TRPV1, and the in silico tools for drug discovery and repositioning.
dc.format.extentdc.format.extent26 páginas
dc.format.extentdc.format.extent2.628Mb
dc.format.mimetypedc.format.mimetypePDF
dc.language.isoLenguaje ISOeng
dc.publisherEditorFrontiers Media SA
dc.rightsDerechosCreative Commons Attribution License (CC BY)
dc.sourceFuentesFrontiers in Pharmacology
dc.subjectPalabras ClavesTransient receptor potential vanilloid type 1 (TRPV1) channel
dc.subjectPalabras ClavesTRP channels
dc.subject.lcshdc.subject.lcshDescubrimiento de drogas
dc.subject.lcshdc.subject.lcshDolor
dc.subject.lcshdc.subject.lcshEstructura
dc.subject.lcshdc.subject.lcshTemperatura
dc.titleTítuloA journey from molecule to physiology and in silico tools for drug discovery targeting the transient receptor potential vanilloid type 1 (TRPV1) channel
dc.typeTipo de DocumentoArtículo de revisión
dc.udla.catalogadordc.udla.catalogadorCBM
dc.udla.indexdc.udla.indexScience Citation Index Expanded
dc.udla.indexdc.udla.indexScopus
dc.udla.indexdc.udla.indexDOAJ
dc.udla.indexdc.udla.indexBIOSIS
dc.udla.indexdc.udla.indexCAB Abstracts
dc.udla.indexdc.udla.indexEMBASE
dc.identifier.doidc.identifier.doi10.3389/fphar.2023.1251061
dc.facultaddc.facultadFacultad de Ingeniería y Negocios


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