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dc.contributor.authorAuthorAmaya-Rodriguez, Cesar A.
dc.contributor.authorAuthorCarvajal-Zamorano, Karina.
dc.contributor.authorAuthorBustos, Daniel
dc.contributor.authorAuthorAlegría-Arcos, Melissa.
dc.contributor.authorAuthorCastillo, Karen
dc.date.accessionedDate Accessioned2024-09-03T19:17:44Z
dc.date.availableDate Available2024-09-03T19:17:44Z
dc.date.issuedDate Issued2023
dc.identifier.citationReferencia BibliográficaFrontiers in Pharmacology, 14, 26 p.
dc.identifier.issnISSN1663-9812
dc.identifier.uriURIhttp://repositorio.udla.cl/xmlui/handle/udla/1354
dc.identifier.uriURIhttps://www.frontiersin.org/journals/pharmacology
dc.description.abstractAbstractThe heat and capsaicin receptor TRPV1 channel is widely expressed in nerve terminals of dorsal root ganglia (DRGs) and trigeminal ganglia innervating the body and face, respectively, as well as in other tissues and organs including central nervous system. The TRPV1 channel is a versatile receptor that detects harmful heat, pain, and various internal and external ligands. Hence, it operates as a polymodal sensory channel. Many pathological conditions including neuroinflammation, cancer, psychiatric disorders, and pathological pain, are linked to the abnormal functioning of the TRPV1 in peripheral tissues. Intense biomedical research is underway to discover compounds that can modulate the channel and provide pain relief. The molecular mechanisms underlying temperature sensing remain largely unknown, although they are closely linked to pain transduction. Prolonged exposure to capsaicin generates analgesia, hence numerous capsaicin analogs have been developed to discover efficient analgesics for pain relief. The emergence of in silico tools offered significant techniques for molecular modeling and machine learning algorithms to indentify druggable sites in the channel and for repositioning of current drugs aimed at TRPV1. Here we recapitulate the physiological and pathophysiological functions of the TRPV1 channel, including structural models obtained through cryo-EM, pharmacological compounds tested on TRPV1, and the in silico tools for drug discovery and repositioning.
dc.format.extentdc.format.extent26 páginas
dc.format.extentdc.format.extent2.628Mb
dc.format.mimetypedc.format.mimetypePDF
dc.language.isoLanguage ISOeng
dc.publisherPublisherFrontiers Media SA
dc.rightsRightsCreative Commons Attribution License (CC BY)
dc.sourceSourcesFrontiers in Pharmacology
dc.subjectSubjectTransient receptor potential vanilloid type 1 (TRPV1) channel
dc.subjectSubjectTRP channels
dc.subject.lcshdc.subject.lcshDescubrimiento de drogas
dc.subject.lcshdc.subject.lcshDolor
dc.subject.lcshdc.subject.lcshEstructura
dc.subject.lcshdc.subject.lcshTemperatura
dc.titleTitleA journey from molecule to physiology and in silico tools for drug discovery targeting the transient receptor potential vanilloid type 1 (TRPV1) channel
dc.typeDocument TypeArtículo de revisión
dc.udla.catalogadordc.udla.catalogadorCBM
dc.udla.indexdc.udla.indexScience Citation Index Expanded
dc.udla.indexdc.udla.indexScopus
dc.udla.indexdc.udla.indexDOAJ
dc.udla.indexdc.udla.indexBIOSIS
dc.udla.indexdc.udla.indexCAB Abstracts
dc.udla.indexdc.udla.indexEMBASE
dc.identifier.doidc.identifier.doi10.3389/fphar.2023.1251061
dc.facultaddc.facultadFacultad de Ingeniería y Negocios


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