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dc.contributor.authorAuthorYbañez-Julca, Roberto O.
dc.contributor.authorAuthorPino-Ríos, Ricardo.
dc.contributor.authorAuthorQuispe-Díaz, Iván M.
dc.contributor.authorAuthorAsunción-Alvarez, Daniel A.
dc.contributor.authorAuthorAcuña-Tarrillo, Edwin E.
dc.contributor.authorAuthorMantilla-Rodríguez, Elena.
dc.contributor.authorAuthorMinchan-Herrera, Patricia.
dc.contributor.authorAuthorCatalán, Marcelo A.
dc.contributor.authorAuthorZevallos-Escobar, Liz.
dc.contributor.authorAuthorVásquez-Corales, Edison.
dc.contributor.authorAuthorYáñez, Osvaldo
dc.contributor.authorAuthorGutiérrez-Alvarado, Wilfredo O.
dc.contributor.authorAuthorBenites, Julio
dc.date.accessionedDate Accessioned2024-09-03T19:17:39Z
dc.date.availableDate Available2024-09-03T19:17:39Z
dc.date.issuedDate Issued2023
dc.identifier.citationReferencia BibliográficaPharmaceutics, 15(8), 21 p.
dc.identifier.issnISSN1999-4923
dc.identifier.uriURIhttp://repositorio.udla.cl/xmlui/handle/udla/1337
dc.identifier.uriURIhttps://www.mdpi.com/1999-4923/15/8/2072
dc.description.abstractAbstractInfusions of Valeriana pilosa are commonly used in Peruvian folk medicine for treating gastrointestinal disorders. This study aimed to investigate the spasmolytic and antispasmodic effects of Valeriana pilosa essential oil (VPEO) on rat ileum. The basal tone of ileal sections decreased in response to accumulative concentrations of VPEO. Moreover, ileal sections precontracted with acetylcholine (ACh), potassium chloride (KCl), or barium chloride (BaCl2) were relaxed in response to VPEO by a mechanism that depended on atropine, hyoscine butylbromide, solifenacin, and verapamil, but not glibenclamide. The results showed that VPEO produced a relaxant effect by inhibiting muscarinic receptors and blocking calcium channels, with no apparent effect on the opening of potassium channels. In addition, molecular docking was employed to evaluate VPEO constituents that could inhibit intestinal contractile activity. The study showed that α-cubebene, β-patchoulene, β-bourbonene, β-caryophyllene, α-guaiene, γ-muurolene, valencene, eremophyllene, and δ-cadinene displayed the highest docking scores on muscarinic acetylcholine receptors and voltage-gated calcium channels, which may antagonize M2 and/or M3 muscarinic acetylcholine receptors and block voltage-gated calcium channels. In summary, VPEO has both spasmolytic and antispasmodic effects. It may block muscarinic receptors and calcium channels, thus providing a scientific basis for its traditional use for gastrointestinal disorders.
dc.format.extentdc.format.extent21 páginas
dc.format.extentdc.format.extent5.308Mb
dc.format.mimetypedc.format.mimetypePDF
dc.language.isoLanguage ISOeng
dc.publisherPublisherMDPI
dc.rightsRightsCreative Commons Attribution License (CC BY)
dc.sourceSourcesPharmaceutics
dc.subjectSubjectValeriana pilosa
dc.subjectSubjectAntispasmodic effect
dc.subjectSubjectEssential oil
dc.subjectSubjectMolecular docking
dc.titleTitleAntispasmodic Effect of Valeriana pilosa Root Essential Oil and Potential Mechanisms of Action: Ex Vivo and In Silico Studies
dc.typeDocument TypeArtículo
dc.udla.catalogadordc.udla.catalogadorCBM
dc.udla.indexdc.udla.indexWoS
dc.udla.indexdc.udla.indexScience Citation Index Expanded
dc.udla.indexdc.udla.indexScopus
dc.udla.indexdc.udla.indexAcademic Search Ultimate
dc.udla.indexdc.udla.indexDOAJ
dc.udla.indexdc.udla.indexEMBASE
dc.udla.indexdc.udla.indexBIOSIS
dc.identifier.doidc.identifier.doi10.3390/pharmaceutics15082072
dc.facultaddc.facultadFacultad de Ingeniería y Negocios


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