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dc.contributor.authorAutorAllel, Kasim.
dc.contributor.authorAutorPeters, Anne.
dc.contributor.authorAutorConejeros, José.
dc.contributor.authorAutorMartínez, José R. W.
dc.contributor.authorAutorSpencer-Sandino, Maria.
dc.contributor.authorAutorRiquelme-Neira, Roberto.
dc.contributor.authorAutorRivas, Lina.
dc.contributor.authorAutorRojas, Pamela.
dc.contributor.authorAutorOrellana Chea, Cristian.
dc.contributor.authorAutorGarcía, Patricia.
dc.contributor.authorAutorAraos, Rafael.
dc.contributor.authorAutorMcGovern, Olivia.
dc.contributor.authorAutorPatel, Twisha S.
dc.contributor.authorAutorArias, Cesar A.
dc.contributor.authorAutorLessa, Fernanda C.
dc.contributor.authorAutorUndurraga, Eduardo A.
dc.contributor.authorAutorMunita, José M.
dc.date.accessionedFecha ingreso2023-08-11T22:09:37Z
dc.date.availableFecha disponible2023-08-11T22:09:37Z
dc.date.issuedFecha publicación2023
dc.identifier.citationReferencia BibliográficaClinical Infectious Diseases, 77, 9 p.
dc.identifier.issnISSN1058-4838
dc.identifier.uriURLhttp://repositorio.udla.cl/xmlui/handle/udla/1177
dc.identifier.uriURLhttps://academic.oup.com/cid/article/77/Supplement_1/S20/7219545
dc.description.abstractResumenBackground: The impact of coronavirus disease 2019 (COVID-19) on antimicrobial use (AU) and resistance has not been well evaluated in South America. These data are critical to inform national policies and clinical care. Methods: At a tertiary hospital in Santiago, Chile, between 2018 and 2022, subdivided into pre- (3/2018-2/2020) and post-COVID-19 onset (3/2020-2/2022), we evaluated intravenous AU and frequency of carbapenem-resistant Enterobacterales (CRE). We grouped monthly AU (defined daily doses [DDD]/1000 patient-days) into broad-spectrum β-lactams, carbapenems, and colistin and used interrupted time-series analysis to compare AU during pre- and post-pandemic onset. We studied the frequency of carbapenemase-producing (CP) CRE and performed whole-genome sequencing analyses of all carbapenem-resistant (CR) Klebsiella pneumoniae (CRKpn) isolates collected during the study period. Results: Compared with pre-pandemic, AU (DDD/1000 patient-days) significantly increased after the pandemic onset, from 78.1 to 142.5 (P < .001), 50.9 to 110.1 (P < .001), and 4.1 to 13.3 (P < .001) for broad-spectrum β-lactams, carbapenems, and colistin, respectively. The frequency of CP-CRE increased from 12.8% pre-COVID-19 to 51.9% after pandemic onset (P < .001). The most frequent CRE species in both periods was CRKpn (79.5% and 76.5%, respectively). The expansion of CP-CRE harboring blaNDM was particularly noticeable, increasing from 40% (n = 4/10) before to 73.6% (n = 39/53) after pandemic onset (P < .001). Our phylogenomic analyses revealed the emergence of two distinct genomic lineages of CP-CRKpn: ST45, harboring blaNDM, and ST1161, which carried blaKPC.es
dc.format.extentdc.format.extent9 páginas
dc.format.extentdc.format.extent882.1 Kb
dc.format.mimetypedc.format.mimetypePDF
dc.language.isoLenguaje ISOeng
dc.publisherEditorOxford University Press
dc.sourceFuentesClinical Infectious Diseases
dc.subjectPalabras ClavesAntibiotic consumption.
dc.subjectPalabras ClavesAntimicrobial resistance.
dc.subjectPalabras ClavesCarbapenemase-producing organisms.
dc.subject.lcshdc.subject.lcshAntibióticos.
dc.subject.lcshdc.subject.lcshCOVID-19 (Enfermedad).
dc.titleTítuloAntibiotic Consumption During the Coronavirus Disease 2019 Pandemic and Emergence of Carbapenemase-Producing Klebsiella pneumoniae Lineages Among Inpatients in a Chilean Hospital: A Time-Series Study and Phylogenomic Analysises
dc.typeTipo de DocumentoArtículo
dc.udla.indexdc.udla.indexSCOPUS
dc.identifier.doidc.identifier.doihttps://doi.org/10.1093/cid/ciad151
dc.udla.privacidaddc.udla.privacidadDocumento públicoes


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