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Molecular Analysis of Full-Length VP2 of Canine Parvovirus Reveals Antigenic Drift in CPV-2b and CPV-2c Variants in Central Chile

dc.contributor.authorAutorVéliz-Ahumada, Alexis
dc.contributor.authorAutorVidal, Sonia
dc.contributor.authorAutorSiel, Daniela
dc.contributor.authorAutorGúzman, Miguel
dc.contributor.authorAutorHardaman, Timothy
dc.contributor.authorAutorFarias, Valentina
dc.contributor.authorAutorLapierre, Lisette
dc.contributor.authorAutorSáenz, Leonardo
dc.contributor.otherCarreraFacultad de medicina veterinaria y agronomiaes
dc.date.accessionedFecha ingreso2022-05-24T16:26:17Z
dc.date.availableFecha disponible2022-05-24T16:26:17Z
dc.date.issuedFecha publicación2021-08-12
dc.identifier.citationReferencia BibliográficaAnimals, 11(8), 11 p.
dc.identifier.issnISSN2076-2615
dc.identifier.uriURLhttp://repositorio.udla.cl/xmlui/handle/udla/1040
dc.identifier.uriURLhttps://www.mdpi.com/journal/animals
dc.description.abstractResumenCanine parvovirus (CPV) is a relevant pathogen, mainly affecting unvaccinated puppies, causing severe and fatal disease. CPV is classified into three variants (CPV-2a, CPV-2b and CPV-2c), which are widely distributed worldwide. These variants may be mutated at specific sites relevant to the immune response against CPV in dogs, and thus previously characterized vaccines may not be effective against new mutants. Therefore, the aim of the present study was to perform a molecular characterization of CPV variants. For this purpose, blood samples from canine patients in central Chile were used. The results of this study showed that the circulating variants were mainly CPV-2c followed by CPV-2b. In addition, genetic mutations were found in regions important for the immune response against CPV, which possibly has implications for the protective immunity generated by available vaccines.es
dc.format.extentdc.format.extent11 páginas
dc.format.extentdc.format.extent1.130Mb
dc.format.mimetypedc.format.mimetypePDF
dc.language.isoLenguaje ISOenes
dc.publisherEditorMDPI 
dc.rightsDerechosCreative Commons Attribution (CC BY)
dc.sourceFuentesAnimals
dc.subjectPalabras ClavesImmune escape.es
dc.subjectPalabras ClavesAntigenic drift.es
dc.subjectPalabras ClavesFull length VP2.es
dc.subjectPalabras ClavesMolecular characterization.es
dc.subjectPalabras ClavesSelection pressures.es
dc.subject.lcshdc.subject.lcshCanine parvovirus.
dc.titleTítuloMolecular Analysis of Full-Length VP2 of Canine Parvovirus Reveals Antigenic Drift in CPV-2b and CPV-2c Variants in Central Chilees
dc.typeTipo de DocumentoArtículoes
dc.udla.catalogadordc.udla.catalogadorCBM
dc.udla.indexdc.udla.indexSCOPUS
dc.identifier.doidc.identifier.doihttps://doi.org/10.3390/ani11082387
dc.udla.privacidaddc.udla.privacidadDocumento públicoes


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